This is an interesting point, and I was thinking this myself when I was wondering what would happen if top level Starcraft players jumped ship to this game.
First, its hard to make a conclusion until we get a better understanding of the limitations within the Commander role.
Secondly, I wonder how much of a handicap it would be to a good Commander when he/she has to deal with recalcitrant champion. RTS players are used to units doing what they want, and when they want it done. Champions, with their attached units, have minds of their own.
Finally, I think that the disparity between a pre-made team and a group of single queue players will be greater in this game....than lets say Dota or LoL.
What I definitely do know is that I can't wait to find out when it comes to the beta, hopefully from firsthand experience. *crosses fingers*
My vote: the team with the best synergy, but that's just stating the obvious i guess.
Edited by WeReWalRuS, 16 April 2012 - 08:11 PM.